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Amlodipine and olmesartan generic, which also have the ability of preventing generation reactive oxygen species in mitochondria (14). In conclusion, the present study has identified mitochondrial dysfunction in PD and provides canada pharmacy generic viagra evidence for the hypothesis of oxidative stress in the pathogenesis of PD. mitochondrial dysfunction is linked to the neuronal pathology, which suggests that mitochondrial dysfunction may be a common denominator in every form of neurodegeneration. Acknowledgments This work was funded by the National Center for Stroke and Memory, National Alliance for Research on Schizophrenia and Depression Grant No. R01 SV110519 (to S.B.). P.H., S.B. and C.C.F. have declared no competing financial interests. References 1. Barnea-Goraly MA Malarkey T Rimm EB, et al. Apoptosis and neurodegeneration in Parkinson's disease: pathophysiological insights. Mol Cell Neurosci. 2009; 20 4 : 757 – 70. 2. Chiu R Leong HJ Liu B, et al. Apoptotic factors in chronic cerebrospinal venous insufficiency-related microangiopathy syndrome. J Toxicol Environ Health A. 2000; 60 6 : 679 – 89. 3. Matsuo P Moriya M Matsunaga M, et al. Effect of aging on brain mitochondria and effects of antioxidants in the aging brain. Brain Res. 2003; 1121 : 47 – 56. 4. Pardo-Rodriguillos H D Barone M, et al. Mitochondrial dysfunction in Alzheimer disease: pathophysiological relevance of oxidative stress. Ann N Y Acad Sci. 2007; 1167 : 381 – 98. 5. Barnea-Goraly MA Malarkey T Rimm EB, et al. Apoptosis induced by H1-anticoagulant in the mouse brain: role of H2-antioxidant and mitochondrial alterations. Proc Natl Acad Sci U S A. 2004; 101 8 : 3174 – 80. 6. Dehghani MM Rizkalla EK Sotoudeh G, et al. Mitochondrial dysfunction in AD. Lancet Neurol. 2012; 17 4 : 621 – 30. 7. Malarkey T Barnea-Goraly MA Sotoudeh G, et al. Acute neurodegeneration and mitochondrial dysfunction in an inbred mouse model of PD. J Neurotrauma. 2010; 29 1 : 27 – 34. 8. Malarkey T Rizzo M Barnea-Goraly MA, et al. Brain mitochondrial dynamics in patients with amyotrophic lateral sclerosis and Parkinson's disease. Proc Natl Acad Sci U S A. 2007; 104 2 : 2419 – 2424. 9. Kim Y-H Chung G-I Lee YK, et al. Mitochondria in brain of patients with multiple sclerosis or motor neuron disease, J Invest Clin Neurol. 2010; 12 10 : 919 – 35. 10. Malarkey T Sotoudeh G Rizkalla EJ, et al. Apoptosis induced by H1-anticoagulant in the mouse brain: interaction microchannels between H2A2 and H2B, in vivo vitro, J Neurosci Res. 2011; 91 12 : 2825 – 35. 11. Dehghani MM Rizzo M Barnea-Goraly MA, et al. Role of oxidative stress and mitochondrial dysfunction in AD. Nat Rev Neurosci. 2010; 10 5 : 339 – 48. 12. Neidhardt R Baillet E Cuniffer Y, et al. Mitochondrial dysfunction promotes axonal in PD. J Neurosci. 2011; 31 16 : 7745 – 53. 13. Malarkey T Dehghani MM Rizzo M, et al. Neuroinflammation, mitochondrial dysfunction, and Parkinson disease. J Neurosci. 2010; 31 2 : 1223 – 35. 14. Malarkey T Sotoudeh G Rizkalla EJ, et al. Neurodegeneration in dystrophic and motor neurons with mitochondrial dysfunction: new perspective. J Psychiatr Res. 2012; 43 4 : 781 – 3. 15. Neidhardt R Baillet E Cuniffer Y, et al. Mitochondrial dysfunction and dystrophic Parkinson disease brain. Ann Neurol. 2005; 54 4 : 577 – 86. 16. Malarkey T Ebert A Rizzo M, et al. Mitochondria are essential for dystrophic neurons and play a role in neuronal pathology. Proc Natl Acad Sci U S A. 2008; 105 7 : 2725 – 9. 17. Sotoudeh G Malarkey T Rizkalla EJ, et al.
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